Your Daily Microplastic Defense
Formulated with 8 science-backed ingredients to support your body’s natural defenses against daily microplastic exposure. 6 ingredients were experimentally shown in academic research to support gut integrity, cellular energy, and hormonal health in the presence of microplastics.
- Fortify your gut barrier
- Support steady, lasting energy
- Strengthen your body’s antioxidant defenses
- Support balanced hormones
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What it does, written plainly.
Deplasto targets what microplastic exposure actually does to your body — draining your energy, disrupting your gut, and throwing your hormones off balance.
The formulation addresses these effects directly: fortifying your gut lining, strengthening your antioxidant defenses, and supporting balanced, lasting energy.
- Gut barrier integrity — six of eight ingredients
- Oxidative-stress response — NAC, milk thistle, lycopene
- Mitochondrial energy — berberine, fenugreek
- Hormonal balance — fenugreek, milk thistle, aloe
Eight ingredients, four pathways.
Each of Deplasto’s ingredients was selected to address a specific pathway that microplastic exposure affects: gut-barrier integrity, oxidative stress, mitochondrial energy, and hormonal balance. No single ingredient does everything. That’s the point.
Each plays a distinct role; together they create a multi-pathway response a single-ingredient supplement can’t replicate. Six have been studied specifically alongside microplastics in peer-reviewed research.
- Fenugreek · NAC · Berberine · Milk Thistle
- Chlorella · Aloe Ferox · Grapefruit · Lycopene
Built backwards from the science.
Most supplements are built around one benefit or one trending ingredient. We built Deplasto differently — starting with the science of what microplastics actually do to the human body, then working backwards to find ingredients with the strongest published evidence for each effect.
The result is a formula where every ingredient earns its place, every dose is intentional, and nothing is included just because it sounds good on a label.
- 150+ citations in the companion eBook
- 7 peer-reviewed publications support the active ingredients
- Formulated and manufactured in the USA
What to expect, week by week.*
Compounding effects — daily support builds over time.
- Weeks 1–2 — Gut lining and detox pathways begin receiving daily support
- Weeks 2–3 — Many customers report improved digestive comfort and steadier energy
- Week 4+ — Antioxidant and hormonal support compounds — built for the long game
Three capsules. Whenever works.
Take three capsules with a glass of water. Morning, noon, or night — consistency matters more than timing.
Each bottle contains 90 capsules — a 30-day supply.
- Take with food for best absorption
- Take at the same time each day to build the habit
- Pair with your tracking app to see the impact
Free, fast, and risk-free.
We provide free 2–5 day shipping within the continental United States.
Not satisfied? We offer a full 30-day money-back guarantee — no questions asked. If Deplasto isn’t right for you, we’ll refund every penny.
- Free continental US shipping · 2–5 days
- 30-day refund window · all sales
- Subscriptions can be paused or cancelled any time
We’re consuming microplastics daily
Microplastics are found throughout our bodies, the food we eat, the water we drink, and the air we breathe.*
Consuming 154,000 microplastics a year does this*
Microplastics affect how you feel through four pathways
Disrupt your gut
Microplastics weaken the gut lining, making it easier for them to pass into your bloodstream.
Stress your cells
Microplastics create oxidative stress in your gut and tissues, putting pressure on your cells.
Strain immunity
Your immune system reacts to the oxidative stress, leading to low-grade cellular inflammation.
Disrupt hormones
Over time, microplastics can impact cellular energy, hormones, and other systems.
A daily defense for the four microplastics pathways*
You can’t avoid all microplastics, but you can support your body’s response.
Enhance energy
Microplastics deplete your energy. Deplasto helps sustain it.
Fortify gut wellness
Microplastics disrupt your gut lining and microbiome. Deplasto strengthens both.
Harmonize hormones
Microplastics disrupt your hormones. Deplasto helps support balance.
Boost immunity
Microplastics stress your cells. Deplasto boosts antioxidant defenses.
Ingredients studied alongside microplastics*
Synergistic compounds
Eight ingredients work together across gut, mitochondrial, and hormonal pathways.
Microplastic targeters
Six ingredients were experimentally shown to support wellness in the presence of microplastics.
Academic publications
At least seven peer-reviewed papers show these ingredients alongside microplastics.
How each ingredient supports your defense*
Six ingredients carry peer-reviewed evidence specifically alongside microplastics. Two more ingredients boost antioxidant support to perfect the formula.
Fenugreek
One of the oldest medicinal plants that supports digestion and steady energy. Shown to remove 90% of microplastics from water. 6-8
N-Acetylcysteine
Powerful antioxidant that goes after oxidizing environmental toxins. Shown to support liver and energy production in the presence of microplastics. 9-15
Berberine
Boosts gut health and supports energy production via glucose metabolism. 16-18
Milk Thistle
Used since the first century, it guards liver cells and balances hormones. Supports the liver's fight against microplastics. 19-21
Chlorella
A nutrient-rich algae that detoxifies and boosts immune defenses. Supports digestion and hormones alongside microplastics. 22-24
Aloe Ferox
One of the most widely-used medicinal plants for calming and cleansing the gut. It's cousin, aloe vera, was shown to filter microplastics from water. 8, 25-26
Grapefruit Extract
Rich in antioxidants that maintain resilience against pollutants. Supports hormones and antioxidants in microplastic studies. 27-29
Lycopene
Fights oxidative stress in heart and gut, supporting a vibrant microbiome. Multiple microplastic studies showning antioxidant and hormonal support. 30-32
The only supplement formulated specifically for microplastic defense*
DeplastoBuilding benefits over time*
You may notice results within a week. The long-term effects compound from there.
Gut & antioxidant boost
- Soothing the gut lining
- Supporting antioxidant activity
- Boosting mental & physical energy
Compounding effects
- Enhancing energy and focus
- Growing gut fortification
- Supporting natural detox pathways
Hormonal support
- May be balancing stress & sex hormones
- May be providing sustained daily energy
- May experience systemic antioxidant support
Long-game support
- Long-term metabolic & hormonal support
- Diverse, resilient gut microbiome
- Enhanced wellness with long-term antioxidant support
Daily exposure deserves a daily defense.
Free shipping. 30-day money-back guarantee. Made in the USA.
What our customers are saying
I've been concerned about microplastics for quite a while and was excited to try this supplement. It is easy to take and as an added benefit made me feel like I have more energy.
I found this brand after watching the new netflix doc about Microplastics. I love what this brand is doing and hope it works! The box was so cute. I've been taking it for a couple weeks now and so far I'm happy with how it's making me feel. Will check back in later to update the review.
I'm concerned about micro plastics in the environment and how it impacts our health. I can tell a difference in my gut health after a week of use. I thought the book had lots of interesting information.
Bought this originally since i’m concerned about my microplastic exposure so was surprised by the nootropic effects. Appreciate that all the ingredients are backed by studies with how new this field of research is
Only been using this for a short time, but I'm already noticing some positive effects. Excited to see how it performs over the next few weeks!
Common questions
Academic References
- Song Y, Zhang J, Yang L, Huang Y, Zhang N, Ma G. Internal and external microplastic exposure in young adults: A pilot study involving 26 college students in Changsha, China. Environ Res. 2024 Dec 15;263(Pt 3):120250. doi: 10.1016/j.envres.2024.120250. Epub 2024 Oct 28. PMID: 39476927.
- Zhang C, Zhang G, Sun K, Ren J, Zhou J, Liu X, Lin F, Yang H, Cao J, Nie L, Zhang P, Zhang L, Wang Z, Guo H, Lin X, Duan S, Cao J, Huang H. Association of mixed exposure to microplastics with sperm dysfunction: a multi-site study in China. EBioMedicine. 2024 Oct;108:105369. doi: 10.1016/j.ebiom.2024.105369. Epub 2024 Sep 28. PMID: 39342804; PMCID: PMC11663775.
- Kadac-Czapska K, Jutrzenka Trzebiatowska P, Mazurkiewicz M, Kowalczyk P, Knez E, Behrendt M, Mahlik S, Zaleska-Medynska A, Grembecka M. Isolation and identification of microplastics in infant formulas - A potential health risk for children. Food Chem. 2024 May 15;440:138246. doi: 10.1016/j.foodchem.2023.138246. Epub 2023 Dec 22. PMID: 38154286.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References are provided for informational purposes only.